MOS200-MOS200M

The MOS200 and MOS200M (motorized version) from Bio-Logic are optical detection modules designed to provide multi-mode spectroscopic detection for kinetics experiments, typically coupled to Bio-Logic SFM stopped-flow mixers.

Detection modes:
– Circular dichroism (CD): protein folding and secondary structure kinetics
– UV/Vis absorbance: enzyme kinetics, FRET, ligand binding
– Fluorescence intensity and anisotropy
– Simultaneous multi-mode detection in a single experiment

Light source and optics:
– 150 W xenon arc lamp for full UV-Vis coverage
– Wavelength range: 160-700 nm (MOS200); 160-900 nm extended (MOS200M)
– Double monochromator: stray light rejection for UV measurements
– MOS200M: motorized wavelength scan for spectral acquisition

CD detection specifics:
– Sensitivity: 0.1 mdeg per shot
– Full equilibrium CD spectra: 185-700 nm
– Kinetics: single wavelength CD vs time
– Coupled to SFM for stopped-flow CD (protein folding, DNA melting)

Stand-alone use:
– Equilibrium CD spectra: proteins, peptides, nucleic acids
– Titration kinetics: manual mixing + spectral monitoring
– Temperature-controlled sample compartment: -10 to +150°C

MOS200M (motorized) additional features:
– Automated wavelength scanning during kinetics
– Multi-wavelength global kinetics analysis
– TRES (time-resolved emission spectra)

NewRoad provides Bio-Logic MOS200 and MOS200M in Israel as part of stopped-flow and CD spectroscopy systems.